Scientific Studies
All our ingredients have studied health benefits:
Studies (Cognition):
https://onlinelibrary.wiley.com/doi/10.1111/jnc.15767 (Lion's Mane)
Hericerin derivatives activates a pan-neurotrophic pathway in central hippocampal neurons converging to ERK1/2 signaling enhancing spatial memory
https://pubmed.ncbi.nlm.nih.gov/37958943/ (Lion's Mane)
Neurotrophic and Neuroprotective Effects of Hericium erinaceus
https://pubmed.ncbi.nlm.nih.gov/24119256/ (Cordyceps)
Neurite outgrowth stimulatory effects of culinary-medicinal mushrooms and their toxicity assessment using differentiating Neuro-2a and embryonic fibroblast BALB/3T
https://pubmed.ncbi.nlm.nih.gov/30878614/ (Chaga)
Inonotus obliquus polysaccharides protect against Alzheimer's disease by regulating Nrf2 signaling and exerting antioxidative and antiapoptotic effects
https://www.mdpi.com/1420-3049/29/11/2516 (Reishi)
The Biological Activity of Ganoderma lucidum on Neurodegenerative Diseases: The Interplay between Different Active Compounds and the Pathological Hallmarks
https://pubmed.ncbi.nlm.nih.gov/33541370/ (Shiitake)
β-Glucan from Lentinula edodes prevents cognitive impairments in high-fat diet-induced obese mice: involvement of colon-brain axis
https://www.dl.begellhouse.com/journals/708ae68d64b17c52,25f9c61f6dbb0698,62066ac8257a4545.html (Maitake)
A Polysaccharide Extract from Maitake Culinary-Medicinal Mushroom, Grifola frondosa (Agaricomycetes) Ameliorates Learning and Memory Function in Aluminum Chloride-Induced Amnesia in Mice
https://pubmed.ncbi.nlm.nih.gov/25821476/ (Turkey Tail)
The Synergistic Beneficial Effects of Ginkgo Flavonoid and Coriolus versicolor Polysaccharide for Memory Improvements in a Mouse Model of Dementia
https://pubmed.ncbi.nlm.nih.gov/25746401/ (Royal Sun)
Anxiolytic Effects of Royal Sun Medicinal Mushroom, Agaricus brasiliensis (Higher Basidiomycetes) on Ischemia-Induced Anxiety in Rats
https://pmc.ncbi.nlm.nih.gov/articles/PMC8625434/ (White Button)
The Effects of Consuming White Button Mushroom Agaricus bisporus on the Brain and Liver Metabolome Using a Targeted Metabolomic Analysis
https://pubmed.ncbi.nlm.nih.gov/23662612/ (Auricularia)
Heat-stable components of wood ear mushroom, Auricularia polytricha (higher Basidiomycetes), inhibit in vitro activity of beta secretase (BACE1)
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https://pubmed.ncbi.nlm.nih.gov/18844328/ (Lion’s Mane)
Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial
https://pmc.ncbi.nlm.nih.gov/articles/PMC8555286/ (Reishi)
Exploration of the anti-insomnia mechanism of Ganoderma by central-peripheral multi-level interaction network analysis
https://pubmed.ncbi.nlm.nih.gov/20804368/ (Cordyceps)
Effect of Cs-4 (Cordyceps sinensis) on exercise performance in healthy older subjects: a double-blind, placebo-controlled trial
https://pubmed.ncbi.nlm.nih.gov/15630179/ (Chaga)
Chaga mushroom extract inhibits oxidative DNA damage in human lymphocytes as assessed by comet assay
https://pubmed.ncbi.nlm.nih.gov/34375514/ (Shiitake)
https://pubmed.ncbi.nlm.nih.gov/25866155/ (Shiitake)
Consuming Lentinula edodes (Shiitake) Mushrooms Daily Improves Human Immunity: A Randomized Dietary Intervention in Healthy Young Adults
https://pubmed.ncbi.nlm.nih.gov/25351719/ (Maitake)
Maitake mushroom extract in myelodysplastic syndromes (MDS): a phase II study
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2017.01087/full (Turkey Tail)
Immunomodulatory Properties of Coriolus versicolor: The Role of Polysaccharopeptide
https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0150191 (Royal Sun Agaricus)
Effect of a Medicinal Agaricus blazei Murill-Based Mushroom Extract, AndoSan™, on Symptoms, Fatigue and Quality of Life in Patients with Ulcerative Colitis in a Randomized Single-Blinded Placebo Controlled Study
https://pubmed.ncbi.nlm.nih.gov/22113068/ (White Button)
Dietary intake of Agaricus bisporus white button mushroom accelerates salivary immunoglobulin A secretion in healthy volunteers
https://www.mdpi.com/2076-3417/12/24/12671 (Black Fungus)
Nutrient Composition, Antioxidant Activities and Glycaemic Response of Instant Noodles with Wood Ear Mushroom (Auricularia cornea) Powder
https://www.researchgate.net/publication/341839361_
Ganoderma lucidum aqueous extract hypobaric hypoxia induced memory deficit